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PEGylation Services

Custom chemical conjugation of Polyethylene Glycol (PEG) polymers to proteins to enhance their pharmacokinetic properties, including increased half-life and reduced immunogenicity.

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Creative BioMart

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PEGylation is a well-established method for improving the therapeutic profile of proteins. By attaching PEG chains, the hydrodynamic size of the protein increases, reducing renal clearance and shielding it from immune detection. We offer site-specific and random PEGylation with various PEG sizes and chemistries.

Key Features & Benefits:

  • Site-Specific and Random Conjugation Chemistries
  • Variety of PEG Reagents (Molecular Weights, Branched, etc.)
  • Optimization for Maximizing Activity and Half-Life Extension
  • Full Analytical Characterization of Conjugates

Relevant Applications:

  • Half-Life Extension of Therapeutic Proteins and Peptides
  • Reducing Immunogenicity of Protein Therapeutics
  • Improving Solubility and Stability of Biologics
  • Formulation Development for Sustained Release

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