Process chemistry is an important stage of drug development for scaling-up drug production or chemical synthesis reactions. It is useful for optimizing economical and efficient drug production. Process chemistry uses reactors and pump systems as well as reagents, standards and buffers.
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Camargo ensures the appropriate regulatory requirements are met every step of the way, streamlining your drug development process all the way to approval.Ready to guide you through the preclinical stage of drug development, Camargo provides strategic support in the following areas: CRO selection Study design Study setup and execution Project management In clinical program development, camargo's focus is unwavering:…
Comprehensive Clinical Development Services Camargo's knowledgeable pharmacokineticists work diligently to determine the proper PK study designs needed to support a successful clinical drug development plan while avoiding unnecessary and costly studies. Expertise includes Phase I PK data analyses — both compartmental and non-compartmental — and interspecies scaling for first-time studies in humans. In addition, our PK staff h…
Hepregen offers a range of DMPK services using their HepatoPac™ co-culture system. Hepregen has experienced scientific staff which work closely with our clients to design assays that meet their needs. We take great pride in our quality results and impeccable customer care. If you don't see your application of interest, our scientists can work with you to create a custom assay.DMPK Services: Metabolite Identification Intr…
Hepregen offers a range of toxicology services using their HepatoPac™ co-culture or Kupffer Cell Model systems. Hepregen's experienced scientific staff work closely with clients to design assays to meet their needs. Hepregen take great pride in their quality results and impeccable customer care. If you don't see your application of interest, their scientists can work with you to create a custom assay.Toxicology Services:…
The 11BHSD2 mouse was produced by injection of a construct, containing 11β-HSD2 cDNA isolated from mouse kidney and cloned into plasmid Clone 26 to recruit the 5.4 kb mouse α–myosin heavy chain (α-MHC) promoter, into pronuclei of C57BL/6 embryos. Transgenic mice were maintained by sibling mating and used as hemizygotes. Model Properties: Coat Color: Black Ideal For: Cardiac hypertrophy, heart failure Strain Code: 510 HE,…
NSE-p25 mice were created by pronuclear injection of an NSE-p25 transgene, produced internally at Pfizer, with transplantation of embryos to pseudopregnant CD-1 females. At weaning genomic DNA was isolated from tail tissue and founder transgenics were identified by PCR that specifically amplified DNA sequences from the human p25 cDNA. Founder mice were bred to FVB/N mates and transgenic offspring were used to maintain the tra…
Developed by C.C. Little in 1921, from a mating of Miss Abby Lathrop’s stock that also gave rise to strains C57BR and C57L. Strains 6 and 10 separated about 1937. To Hall in 1948 from The Jackson Laboratory. To NIH in 1951 from The Jackson Laboratory at F32. To Charles River in 1974 from NIH. Model Properties: Coat Color: Black MHC Haplotype: H2b Ideal For: general multipurpose model, diet-induced obesity, transgenic…
Silvers and Billingham began brother x sister matings with selection for histocompatibility in 1958 from a brown mutation in a stock of wild rats maintained by King and Aptekman in a pen-bred colony of rats trapped from the wild in 1930 by King at the Wistar Institute. To Charles River from Radiobiology Institute, Netherlands in 1976. Model Properties: Coat Color: Non-agouti brown MHC Haplotype: RT1n Ideal For: Geneti…
The New Zealand White rabbit was obtained in 1991 by Charles River Canada (CRC) from Kitayama Labs K.K. of Nagano Prefecture, Japan. Model Properties: Coat Color: White (albino) Ideal For: General multipurpose model Strain Code: 052
Optim is an innovative analytical instrument designed to probe multiple protein stability-indicating parameters at high speed using ultra-low sample volumes of proteins and other molecules. Compact and robust, using a light scattering and fluorescence technology in a configuration never seen before and controlled by an all-new easy-to-use intuitive software package, the Optim 2 has been designed to reduce the time and cost of…
Formulation Development SpecialistsWith a keen understanding of early stage development and clinical trial requirements, Aesica guides their customers through the processes of new medicine and material development for Phase 1 and Phase 2 clinical trials. They understand that their customers also need to maximise their budget effectiveness by minimising the amount of experimentation without sacrificing quality levels.Typical do…
In the fast growing Biopharma market, the need for ultra clean sterile packaging is growing at a high speed, often driven by regulatory authorities and cGMP regulations. Eliminating every risk of delivering a contaminated parenteral drug that might be hazardous to a patient's health or even his life is the key concern that drives these regulations.The source for all your Cleanroom Packaging - with the Newform™ product line, r…
Marken’s network fulfills the global movement of API from the point of manufacturing to CMOs and primary packagers. Marken optimizes API logistics around the globe with continuous temperature monitoring, documented transit custody and a worldwide network of offices, providing end-to-end quality-assured supply chain services.With Marken’s experience and expertise they excel in assisting companies to achieve the most expeditiou…
Marken offers validated packaging solutions for the widest range of temperatures to ensure that your products maintain their integrity throughout the shipment. BIOsystem boxes are designed and engineered specifically for the transportation of frozen and controlled ambient biologics. Your samples have specific temperature profiles that must be strictly maintained to preserve their efficacy. Marken is uniquely qualified to prov…
TOWER has the resource and experience to design and qualify solutions for all standard temperature-control ranges. These are developed to meet rigorous internal design criteria or for client-led validation projects.All standard KT configurations are designed to operate all year round in worldwide distribution environments. A KT configuration is one product with one instruction.The KryoTrans System Features: Robust reusabl…
Premium Shipping Containers for Premium Research Models. SAGE® Labs now offers plastic containers, developed for shipping your research models more safely. These containers are sturdier than cardboard boxes, for excellent protection against contaminants, breakage and leakage en route to your lab.The patented design also ensures unsurpassed convenience and ease of handling at every stage.SAGE® Labs Shipping Containers Features…
Recombination Activation Genes (Rag) encode enzymes that play an important role in the rearrangement and recombination of the genes of immunoglobulin and T cell receptor molecules during the process of V(D)J recombination. Rag1 knockout rats lack mature B and T lymphocytes. Rag1 Knockout Rat Characteristics: 29 bp deletion within Exon 2 on chromosome 3 Homozygous Rag1 knockout rats display loss of RAG1 protein via Wester…
In vivo model for xenograft and Immunology studies. Recombination Activation Genes (Rag) encode enzymes that play an important role in the rearrangement and recombination of the genes of immunoglobulin and T cell receptor molecules during the process of V(D)J recombination. Rag1 knockout rats lack mature B and T lymphocytes.Rag1 Knockout Rat Characteristics: 29 bp deletion within Exon 2 on chromosome 3 Homozygous Rag1 k…
The Prkdc gene encodes the catalytic subunit of a nuclear DNA-dependent serine/threonine protein kinase (DNA-PK). DNA-PK is required for the non-homologous end joining (NHEJ) pathway of DNA repair, which rejoins double-strand breaks. It is also required for V(D)J recombination, a process that utilizes NHEJ to promote immune system diversity. Mature B and T cells are critical components for an adaptive immune system. DNA-PK kn…
The Low-Density Lipoprotein (LDL) receptor is directly involved in the development of atherosclerosis, due to accumulation of LDL cholesterol in the blood. Ldlr (-/-) rats show elevated serum cholesterol levels. Ldlr Knockout Rat Characteristics: This model possesses a 337 bp deletion and 4 bp insertion within Exon 4 on chromosome 8 Homozygous knockout rats display loss of LDLR protein via Western blot Homozygous knoc…
Leptin is essential for energy intake and expenditure. It is one of the most important adipose-derived hormones, being primarily expressed in adipocytes of white adipose tissue. Loss of function of Leptin creates an uncontrolled appetite leading to severe obesity and abnormal metabolism, making this a useful model for the study of lifestyle diseases, such as obesity, diabetes, atherosclerosis, high cholesterol and high blood…
Rabbits are a preferred model in hypertension and atherosclerosis studies due to their convenience of various physiological and surgical manipulations. ApoE Knockout rabbits have drastically elevated cholesterol and triglycerides, making it an excellent model of human heart disease. ApoE Knockout Rabbit Characteristics: 8 bp deletion within Exon 3 Homozygous knockouts exhibit complete loss of ApoE protein via Western bl…
Cyclooxygenase (COX), also known as prostaglandin synthase (PHS) and prostaglandin endoperoxide synthetase (PES), is an enzyme that is responsible for formation of important biological mediators called prostanoids, including prostaglandins, prostacyclin and thromboxane. Rats deficient in COX1 can be used for studying inflammation, thrombosis, vascular defects, platelet defects and alterations in platelet aggregation.Cox1 Knoc…
Galectins have been implicated in inflammation and cancer, and are useful targets for development of new anti-inflammatory and anticancer therapies. LGALS1 (GAL1) may act as an autocrine negative growth factor that regulates cell proliferation. Lgals1 (gal1) Knockout Rat Characteristics: Homozygous knockout rats display loss of LGALS1 protein via Western blot Background Strain: Sprague-Dawley Research Applications:…
