Utility of cerebrospinal fluid Kappa Free Light Chains
Tuesday, December 9, 2025 at 15:00 GMT / 16:00 CET / 10:00 EST / 07:00 PST
Analysis of oligoclonal bands in paired cerebrospinal fluid (CSF) and serum is the principal cornerstone of the neuroimmunology diagnostic laboratory. CSF Kappa Free Light Chain (kFLC) introduction is revolutionizing how healthcare professionals view laboratory presentation of intrathecal inflammation.
In this webinar, Nick Armfield MSc MIBMS, senior biomedical scientist in the Walton Centre NHS Neuroimmunology lab, will explore core principles of this new test, including:
- CSF κFLC technical and clinical contextualization
- CSF κFLC result format options – what scientists and clinicians will encounter when referring CSF κFLC for upcoming changes to multiple sclerosis diagnostic guidelines
- CSF κFLC laboratory platforms and accessibility to non-specialized centers for assessing intrathecal inflammation
Learning objectives
- Describe the utility of CSF kFLC as a non-specific tool for laboratory input into multiple sclerosis diagnosis
- Summarize CSF kFLC formats and tools for multiple sclerosis
- Explain how the test can be implemented into routine lab testing and the outlook for future research
Who should attend?
Lab directors, lab technicians, neurologists, and neuroimmunologists.
Accreditation statement
SelectScience® is approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E.® Program.
Level of instruction: Intermediate
Speakers
Nick Armfield MSc MIBMS is a senior biomedical scientist at The Walton Centre NHS Foundation Trust. He gained a BSc (Hons) at Liverpool John Moores University and qualified at Salford Royal in biochemistry. Following a specialist role at Liverpool Clinical Laboratories, a Biomedical Sciences MSc at the University of Chester and over a decade’s experience in NHS laboratories, he is now a specialist in neuroimmunology. Armfield's main professional interests are laboratory signatures of intrathecal inflammation by varying techniques including mass separation, immunoassay and mathematical modelling to enhance paraclinical input to multiple sclerosis, and other neuroinflammatory diseases. He also has a very keen interest in translation biomedical science.
Moderator
