How gene editing heralds new therapeutic era

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Powerful gene editing technologies and the next generation of tools

ddPCR to innovate replication-competent virus testing

The latest Droplet Digital™ PCR (ddPCR™) technology and kits could provide a time-saving solution to transform replication-competent virus (RCV) testing in gene therapy workflows, helping to ensure the safety of new therapeutics. For Dipika Gurnani, a Product Manager at Bio-Rad Laboratories, the promise of these approaches is an everyday focus. “My passion has always centered around rare diseases that have lacked effective diagnosis and treatment options,” she explains. “My primary objective at Bio-Rad is ensuring that the products in our gene therapy portfolio reach end-users and help researchers to bring safe and efficacious therapies to the market.”

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​Dr. Krishanu Saha
A step-by-step workflow for a HPRT knock-out experiment in an adherent cell line

This step-by-step tutorial video demonstrates the process of conducting a HPRT gene knock-out experiment in a HEK293 adherent cell line. See how to design the experiment; prepare both cells and reagents; conduct post-transfection assessment; perform genomic cleavage detection; and isolate and clonally expand the culture for further experimentation.

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What next for CRISPR after first therapeutic approvals?

As we celebrate the first regulatory approval of a gene-editing based therapeutic, Casgevy, for the treatment of sickle cell disease and transfusion-dependent β-thalassemia, we consider the gene-editing challenges that must be overcome before CRISPR gene-editing technology becomes a common treatment modality.

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​Dr. Krishanu Saha

The latest advances in cell and gene therapy research

Explore the latest developments in cell and gene therapy with fellow scientists, manufacturers, and regulatory experts.

The cell and gene therapy products reviewed by you

Clonal Genes by Twist Bioscience

"Fast, cheap, high-quality genes" - Andrew Lezia, Port Therapeutics

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SeqStudio Flex Genetic Analyzers by Thermo Fisher Scientific

"This has revolutionized our lab" - Sanny Khurdia, Concordia University

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MiSeq Personal Sequencer by Illumina

"The results were reproducible when run by anyone in the lab!" - Damian Yap, University of British Columbia

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