Proteomics is revolutionizing our understanding of biology, helping researchers to unravel disease mechanisms and uncover promising new drug targets. It is also providing new tools to identify novel biomarkers for diagnosis, prognosis, and therapeutic monitoring.

As analysis tools such as mass spectrometry (MS) have become more sensitive and efficient, sample preparation in proteomics has emerged as a significant bottleneck, underscoring the need for advanced technologies that enable precise and reproducible protein recovery across diverse sample types.

In this content hub, developed in partnership with Tecan, we present a collection of expert resources that highlight how the latest automated sample preparation platforms, reagents, and software can address these challenges, ensuring consistency and accuracy across experiments while boosting scalability. Read on to discover how these tools are empowering researchers across low- to high-throughput proteomics to accelerate discoveries and unlock deeper proteomic insights to advance the field.

One of the most significant barriers in proteomics research is the need for sophisticated sample preparation techniques. Manual processing of large sample cohorts requires considerable hands-on time, which can slow down the speed of studies and create the risk of human error. Fortunately, automated technologies capable of performing sample prep for medium to high-throughput proteomics have recently become available.

In the resources highlighted below for example, discover how end-to-end sample prep automation for mass spectrometry-based proteomics can now be achieved using ENRICH-iST technology on Tecan’s Fluent^® Automation Workstation with the Resolvex^® i300 module. With these tools, users can go from plasma samples to dried peptides in less than 6 hours, enabling 96 samples to be prepared in a single working day.

Plus, learn how the Resolvex^® i300 and Resolvex^® A200 platforms can provide scalable solutions suitable for several proteomics applications. Download this technical note to see how these platforms can be used with Tecan’s AffinEx Protein A Capture matrix to provide a more cost-effective solution for antibody purification.

As proteomics labs scale up sample throughput through automated workflows, they encounter new challenges in managing data complexity, maintaining workflow efficiency, and ensuring reproducibility across experiments.

Tecan’s LabNavigator^™ and Introspect^™ software work together to address these issues, creating a cohesive digital ecosystem that streamlines workflow execution and enhances data integrity.

LabNavigator^™ is a cloud-based, intuitive digital tool that guides technicians through workflows using a single interface – regardless of reagents, labware, throughput, or format. Its easy-to-follow, end-to-end workflows enable entry-level staff to operate systems effectively, enhancing lab accessibility while improving the consistency and quality of research.

Introspect^™ complements this platform by offering a real-time overview of instrument and fleet performance, allowing lab managers to maximize instrument utilization and streamline lab operations. With user-friendly dashboards and AI-backed recommendations, Introspect^™ enables lab managers to resolve bottlenecks and boost productivity. Learn more about how these tools can transform lab operations in the resources below.

By addressing bottlenecks in sensitivity, reproducibility, and standardization, Tecan is helping researchers harness the full potential of proteomics, advancing both academic and industrial goals in drug discovery and disease research.

As an all-in-one provider, the company offers integrated automation solutions for every stage of sample preparation – from sample transport and LIMS registration to solid-phase extraction prior to analysis. These solutions not only bring resource and cost savings but also open new avenues in proteomics research, ultimately accelerating the development of novel drugs and treatments for the many diseases that affect individuals worldwide.

Resolvex^® i300

Tecan's advanced automation solutions are tailored to address the complexities of proteomics sample preparation. The Resolvex^® i300 module, an integrated component of the Fluent^® automation workstation, consolidates sample prep, cleanup, evaporation, and resuspension tasks onto one platform.

Resolvex^® Prep

Introducing Resolvex Prep^®, automated sample preparation for low- to medium-throughput chromatography and mass spec labs. Resolvex Prep^® streamlines the process of preparing samples for multiple instruments and methods, delivering them into sealed vials for analysis, reducing manual inefficiencies and errors.

Fluent^® Laboratory Automation Workstation

Tecan has reinvented automation with the Fluent^® Laboratory Automation Workstation, a unique instrumentation concept built around the application-specific needs of your laboratory. Fluent^® breaks new ground, delivering more capacity and increased speed. It provides superior precision, throughput and walkaway time, making it easier to get more done, more confidently.

Resolvex^® A200 Automated ppSPE Workstation

Sample preparation continues to be the most time-consuming part of an analytical workflow. Tecan’s range of smart consumables, coupled with its automation expertise, can help improve the throughput and quality of your sample preparation workflow.

Introspect™

Introspect™ is a laboratory insights tool that offers an intuitive user experience and employs advanced data science. It converts instrument and workflow data into actionable insights, maximizing the utilization, quality, and performance of instrument fleets.

Antibody purification: AffinEx™ Protein A

AffinEx™ Protein A is a dry-state protein purification device offered in Tecan's unique Narrow Bore Extraction™ (NBE™) format. Protein A binds to the Fc-region of monoclonal antibodies while the NBE format provides increased interactions between the target analyte and sorbent bed.