Implementing accurate-mass mass spectrometry for biotherapeutic development

Despite the widespread practice of exact-mass mass spectrometry (MS) analysis in the biotherapeutics development processes, experienced MS users are typically required to manage the instrument operation, data processing, and interpretation. In this study, Waters reports on the development of a new high-performance bench-top orthogonal acceleration time-of-flight (oa-TOF) LC-MS system (BioAccord) designed with simplified and optimized operation modes to deliver automated, accurate, and reproducible mass measurements for proteins, peptides, and released glycans.