An Excellent Range of Anti-human PGP 9.5 Antibodies

Protein Gene Product 9.5 (PGP 9.5), also called Ubiquitin Carboxyl-terminal Hydrolase (UCH) Isozyme L1, is a neuronal UCH isoenzyme involved in the regulation of the ubiquitin pathway.

There is evidence that disorders such as Alzheimer’s Disease (AD) and Parkinson’s Disease (PD) are related to the accumulation of ubiquitin caused by a mutation or reduction in PGP 9.5. In particular, a mutation in PGP 9.5 has been directly associated with the early onset of familial PD, and the protein is also down-regulated in idiopathic PD. Reduced PGP 9.5 function may also jeopardize the survival of neurons, which maybe another causative factor of these diseases.

AbD Serotec offers a wide range of reagents specific to PGP 9.5, including our rabbit anti-human PGP 9.5 antibody, 7863-0507. This antibody stains neuronal cell bodies and axons in the CNS and periphery, small nerve fibers in peripheral tissues, neuroendocrine cells in the pituitary, thyroid, pancreas, and tumors of the diffuse neuroendocrine system. It is paraffin-reactive and also suitable for Western blotting. As well as being a marker for human PGP 9.5, this antibody can also identify the protein in rodents, pig, sheep, dog and cat.

Our mouse anti-human PGP 9.5 antibody, 7863-1004, is a monoclonal alternative. Again it is paraffin-reactive, showing similar staining patterns to the polyclonal, but less cross-reactivity with other species. It can also be used for ELISA assays.


References:

Choi, J. et al. (2003) J. Bio. Chem. 279:13256-13264
Drapkin, P. T. et al. (2002) BMC Dev. Biol. 2:1-11
Lam, A. Y. et al. (2000) PNAS 97:9902-9906
Lombardino, A. J. (2005) PNAS 102:8036-8041