Analysis of subvisible and visible aggregation in lentiviral vectors with Aura GT

Third-generation lentiviral vectors (LVV) are promising nucleic acid delivery vehicles for cell and gene therapies. LVVs are more complex biomolecules compared to standard protein biologics. They are comprised of a lipid envelope, surface proteins, and nucleic acid material – all of which present challenges for physical and chemical stability. Discover how Aura GT™ requires as little as 5 µL of sample to quantitate and characterize visible and subvisible particles using backgrounded membrane imaging (BMI), and how the biological and chemical nature of large lentiviral aggregates can be identified using fluorescence membrane microscopy (FMM).