Application note: An optimized, multiplexed assay for screening ex vivo conditions which increase memory T cell frequency
Download this application note from Sartorius to discover how the need to monitor T cell phenotype and function for improved T cell expansion protocols was addressed with a T cell memory cell and cytokine profiling assay
25 Jun 2020
Ex vivo expansion of T cells is a critical process in bio-manufacturing of adoptive cell therapies such as chimeric antigen receptor (CAR) T and tumor infiltrating lymphocyte (TIL) therapies.
Recent clinical studies suggest that ex vivo T cell expansion protocols generating higher percentages of T memory stem cells (Tscm), central memory T cells (Tcm) in the total cell product are critical to significant clinical improvements in adoptive cell therapies.
Download this application note to learn how the need to monitor T cell phenotype and function for improved T cell expansion protocols was addressed with a T Cell Memory Cell and Cytokine Profiling assay that enabled measuring memory cell phenotype, cell viability and effector cytokine release in the same sample well in a miniaturized assay format.
