Automated Combinatorial Flow Chemistry with the FlowSyn Auto-LF Loop Filling Module from Uniqsis

The FlowSyn Auto-LF loop filling module from Uniqsis is a powerful and highly efficient module that allows chemists to automatically perform in sequence combinatorial flow chemistry experiments. Each experiment can be run under different conditions and utilize a different set of reagents or monomers.

Incorporating a separate liquid handler and fraction collector, FlowSyn Auto-LF enables sample loop filling in preparation for the next experiment to take place before the current experiment has finished, thereby reducing overall reaction runtimes. Additionally, the module has no injection ports to leak or block, and the fully integrated robust wash protocols minimize the risk of cross-contamination. Sampler calibration ensures that reagent ‘plugs’ are positioned precisely in the loops to ensure volumetrically accurate partial loop filling that avoids wasting precious starting materials when performing reactions with different stoichiometries.

The powerful PC software included with FlowSyn Auto-LF makes real-time reaction monitoring and data logging straightforward. Data can be saved as a log file for each experiment to give an audit trail.

The Uniqsis FlowSyn™ is a compact integrated continuous flow reactor system designed for easy, safe and efficient operation. The FlowSyn™ range includes models for performing single or multiple homogeneous or heterogeneous reactions, either manually or automatically. The range of chemistries that can be explored with Uniqsis’ integrated and modular flow chemistry systems grows ever wider and is exemplified by the growing number of applications published both in the academic press and in Uniqsis’ own application notes.