Cellexus Biosystems plc launches the CellMaker Lite2<sup>TM</sup> – the latest generation of its novel disposable bioreactor

20 May 2007

Cellexus Biosystems plc, the specialist in the design, manufacture and commercialisation of novel disposable technology for growing cells, announces the launch of the CellMaker Lite2™ disposable bioreactor.

The CellMaker Lite2 is the latest generation of disposable bioreactor from the Company and incorporates a wealth of new features, many of them direct requests from early customers. One of the key features is that the CellMaker Lite2 can now control the flow of blended gases that are required to grow mammalian cells. The system can also deliver gases to the novel aeration system in the base of the disposable cell culture bag (the CellexusBag™) and to the large surface area above the cell culture (called the headspace) independently of each other, a considerable advantage over other products currently available. Other features include a 60% smaller footprint so that less bench space is required, new control software and several other changes to make it easier for the operator to install and start the cell culture process without the need for a service engineer or other installation specialist.

Kevin Auton PhD, Chief Executive of Cellexus Biosystems plc, said: “The CellMaker Lite2 is another important milestone for the Company, as it incorporates the many design innovations that our customers have suggested to us. Our customers are a creative group of scientists who provide valuable feedback and ideas. It is a big step for a company to deliver to market a second-generation product whose design is driven directly by customers. Many customers requested more flexibility whilst retaining the simplicity of the first-generation product. We have also been able to accommodate requests for easier operation and a smaller unit size to address limited bench space in busy laboratories.”

“The CellMaker Lite2 is positioned to utilise our second generation of CellexusBags, which feature novel disposable sensors to measure pH and the concentration of dissolved oxygen in the cell culture medium. These sensors will be incorporated as standard in every CellexusBag, giving a level of culture control and monitoring which has been difficult to achieve without the use of expensive, re-usable sensors. Our disposable sensors eliminate the risk of contamination as, unlike alternative products in the marketplace, they are integrated into the disposable CellexusBag during manufacture.”

Test marketing of the CellMaker Lite2™ at BioProcess International (Paris), BIO2007 (Boston, USA) and Protein Engineering Summit (Boston, USA) met with an enthusiastic response.

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