Cisbio extend the Kinase platform and present the latest application of IP-One HTRF^®

Cisbio’s HTRF^® KinEASE™ assay for screening serine/threonine kinases (STKs) now extends to tyrosine kinases (HTRF^® KinEASE™TK). The assay, developed in partnership with Millipore, uses a unique substrate containing a single phosphorylation site recognized by Eu(K)-labelled anti-phospho-tyrosine antibody. Over 60 tyrosine kinases have already been validated.

Cisbio’s IP-One assay is the first HTS system that can easily detect inositol(1)phosphate (IP1), which tightly correlates with Gq-coupled receptor activity. Moreover, IP-One HTRF^® is the unique HTS functional assay for slow acting agonist screening and for inositol mono-phosphatase (IMPase) inhibitors identification. With IP-One and cAMP, Cisbio offers a reliable and functional platform for investigating and screening GPCR activity.

All Cisbio’s kits are available in small and jumbo sizes for HTS and profiling applications.