Enhancing the sensitivity of top-down and bottom-up proteomic applications using the new HALO 1.5 mm ID column

In this application note, Advanced Materials Technology presents the HALO^® 1.5 mm ID column, which shows enhanced sensitivity and solvent savings on a conventional UHPLC system. The only modification required to realize this performance is the reduction of extra column volume, which can easily be done by the consumer. Decreasing the internal diameter of a column can increase detector response, lower solvent consumption, and bring multiple benefits to the overall analysis workflow. This has fueled the development of capillary columns which provide very high performance, but require specialized instruments in order to realize that performance.