Expanded use for IntelliCap with Further CE Mark for Aspiration of Fluids

The small, pill-shaped IntelliCap wireless medical device is opening up research opportunities into the impact of the small intestine microbiota on health and disease. For the first time, scientists have been able to obtain and analyse samples of the small intestine’s microbiome in a non-invasive way. A greater understanding of the significant role the gut microbiome plays in health and disease and is likely to bring opportunities for new therapeutics.

The IntelliCap CR system, which already had CE Marking for drug delivery and the real-time measurement of temperature and pH on the gastrointestinal tract, has recently been further approved for the aspiration of fluids. Measuring just 11 x 26 mm, IntelliCap was developed by Medimetrics, a company pioneered by Philips, with offices in Germany, the Netherlands and the USA. The IntelliCap system is already being successfully used by the pharmaceutical industry for the targeted and controlled delivery of drugs into the gut.

“Understanding the environment of the small bowel is very difficult. For the first time, this device presents scientists with a convenient and non-invasive method of exploration,” said Jeff Shimizu, Chief Technical Officer, Medimetrics. “By extending its use, the IntelliCap technology has the potential to play an even more powerful role in the development of therapeutic products.”

To demonstrate the capabilities of the IntelliCap fluid sampling technology, Medimetrics joined forces with NIZO food research and Wageningen University, also in the Netherlands. They carried out a pioneering research study which used the IntelliCap system to take samples from the small intestine which were then sequenced and analyzed by scientists both at NIZO and the university. Preliminary results are encouraging and their detailed findings are expected to be published in a prestigious journal later in 2015.

Dr Michiel Kleerebezem, from the university’s Host Microbe Interactomics Group, is one of the leaders in this study. He commented: “The role of the small intestine in human health is potentially of greater importance than that of the large bowel. However, using traditional methods, it has been very complicated to take samples, and this has held back research.

“We wanted to evaluate the IntelliCap performance in being able to gather gut samples and retain sample integrity so that we could study bacterial communities in the small intestine - which had previously been hard to access. While we cannot yet discuss our findings in detail, early indications are that the capsule presents a breakthrough for scientific research in the small intestine.” And Dr Kleerebezem added: “Sampling using the IntelliCap enabled us to obtain reliable and well preserved small intestinal samples that more clearly and with higher resolution reflected the impact of treatment, as compared to faecal samples.”

The project has been financially supported by the European Regional Development Fund as part of the OP-Zuid programme, and by the Dutch Ministry of Economic Affairs, Agriculture and Innovation.