Exploring genome structure and gene expression using super-resolution microscopy

A critical step in the central dogma of biology, the flow of genetic information within a biological system, is the transcription of DNA into RNA. RNA transcripts serve certain functions within a cell, and these functions can be influenced by a variety of factors. Here, Bruker Fluorescence Microscopy highlights Dr. Guy Nir's research program which focuses on how genome structures can shape transcriptional regulation in different biological systems, utilizing super-resolution microscopy as a main technology for investigation. His lab studies this phenomenon at the single-cell level, enabling simultaneous detection of gene expression and structure that is critical for determining their relationship. This relationship between genome structure and function can be explored in a variety of biological systems, lending to several interesting research efforts transcending disciplines.