First UK patients enroll in Phase 3 clinical trials of LMTX™ for Alzheimer’s Disease

Coinciding with Dementia Awareness Week in the UK, TauRx Therapeutics Ltd announced that the first of more than 100 UK patients have enrolled in the global Phase 3 clinical trials of LMTX™ for mild to moderate Alzheimer’s disease.

“The initiation of our clinical studies in the UK marks an important step forward in our quest to find a disease-modifying agent that can help slow or halt the progression of Alzheimer’s disease,” said Prof. Claude Wischik, Executive Chairman and Co-Founder of TauRx Therapeutics. “Unlike cancer, for Alzheimer’s there are no ‘Alzheimer’s survivors’, so a medicine that can keep people functioning and at home longer is essential.”

The Phase 3 trials of the tau aggregation inhibitor target ‘tau tangles’ in the brain, and could provide the first definitive data on a tau-based treatment that dissolves the tangles and slows or halts Alzheimer’s disease.

Prof. Wischik added, “It is hoped that this study will shed new light on our understanding of how tau tangles form, their role in dementia, and ultimately how to stop them from spreading in the brain. LMTX™ could also provide a basis for preventive treatment of Alzheimer’s before any symptoms appear.”

The two large, Phase 3 studies will involve over 1,500 patients inmore than 20 countries, with about 16 medical centres participating in the UK. These studies culminate three decades of research by Professor Claude Wischik and colleagues at TauRx Therapeutics, a spin-out company from the University of Aberdeen, Scotland established 11 years ago. According to the UK’s Alzheimer’s Society, there are currently 800,000 people in the UK living with dementia and this is expected to grow to over a million people by 2021. Currently no treatments are available to stop or reverse this devastating disease, which is now one of the leading causes of death in the UK.

For more information and updates about the Phase 3 clinical trials in Alzheimer’s disease or TauRx Therapeutics, patients and carers can visit www.alzheimersglobalstudies.net.