Four ways to better water quality in LC-MS

High purity water is key to the success of analyses performed using (ultra) High-Performance Liquid Chromatography-Mass Spectrometry, (U)HPLC-MS — or as it is more commonly known, LC-MS. Even so, chromatographers may consciously select top-quality salts and organic solvents for mobile phase preparation, but not apply the same level of care when choosing their source of high purity water. Here, Merck discusses several aspects of working with high purity water in LC-MS analyses including quality and handling.