Genetically engineered TCR-T lead to target solid tumors

Zelluna Immunotherapy, a biopharma company developing T-cell receptor (TCR) guided adoptive cell therapy products for the treatment of multiple solid cancers, presented data on its lead TCR compound, ZI-H04 at a poster session during the Annual Meeting of SITC 2019.

Jens-Peter Marschner, Chief Medical Officer, Zelluna Immunotherapy delivered the poster presentation on ZI-H04, Zelluna’s lead candidate. The poster was entitled “ZI-H04 - A novel MHC class II restricted TCR based cellular therapy targeting hTERT to treat solid tumors”.

ZI-H04 is an autologous, genetically engineered TCR-T, designed to target solid tumors with large patient populations. It will enter clinical development in autumn 2020. The details on ZI-H04 Jens-Peter included the scientific background of the product, the non-clinical rationale and the clinical design of the phase I/II study.

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