Genome engineering for cell therapy manufacturing

Genome engineering has great potential for cell and gene therapy development due to its role in altering genomes to enhance immune cell and regenerative medicine therapies. In this brochure from Bio-Techne, explore the TcBuster™ system, a non-viral gene delivery tool based on the DNA transposon system from the red flour beetle, that enables stable gene transfer into various cell types. TcBuster supports the generation of transgenic mammalian cells, facilitating multigene transfer and integration with CRISPR-mediated knockouts in a single operation. The system is a valuable tool for both proof-of-concept studies and manufacturing scale process development, offering simple installation, integration with existing software, and scalability from research to clinical and commercial stages with reduced batch-to-batch variability.