High-content screening of neuronal toxicity using iPSC-derived human neurons

The nervous system is sensitive to the toxic effects of many chemical compounds, environmental agents and certain naturally occurring substances. High-content imaging using induced pluripotent stem cells (iPSCs) of human origin can be applied to examine neurotrophic, neuroprotective, or neurotoxic effects of pharmaceutical drug candidates or environmental contaminants. Molecular Devices demonstrates neuronal toxicity screening via automated endpoint and live-cell assays using iPSCs and Molecular Devices systems and software.