Hot melt extrusion: A holistic insight for process optimization

Hot-melt extrusion (HME) is gaining attention in the pharmaceutical industry due to its high manufacturing efficiency, economic benefits, and ability to develop versatile dosage forms. In this upcoming webinar, hear from Dr. Rui Chen, Global Application Manager, Spectroscopy, Thermo Fisher Scientific, to learn more about HME and process optimization using near-infrared spectroscopy, Raman microscopy, and scanning electron microscopy (SEM).

Watch this webinar to hear how HME can be utilized to develop versatile dosage forms, especially for poorly soluble active pharmaceutical ingredients (API). Chen will discuss a case study on acetaminophen (APAP) in hydroxypropyl methylcellulose (HPMC) matrices prepared by HME, using an integrated analytical approach involving Fourier transform near-infrared spectroscopy (FT-NIR), SEM and Raman microscopy. Data from different analytical techniques are correlated and reconciled to elucidate the impact of process parameters, such as temperature and screw speed, on the formation of solid dispersions. Chen also discusses in-line process stability monitoring using FT-NIR.

Watch this webinar to learn:

• Why FT-NIR and MVA (multivariate analysis) is a superb PAT (process analytical technology) technique for HME process optimization and monitoring to ensure product consistency
• How THz Raman imaging can shed light on HME process optimization
• How an integrated analytical approach can enhance the understanding of HME for better formulation and process optimization

Who should attend:

• Drug formulation scientists, drug development scientists, and PAT engineers in pharma, CMOs and CDMOs
• Analytical chemists supporting drug development
• Laboratory managers/directors/supervisors
• Quality control and assurance labs
• Industry regulators

The live webinar and Q&A session will take place on Monday, March 23, at:

• 16:00 GMT
• 12:00 EDT
• 09:00 PDT
• 17:00 CET

Register to watch the full webinar here>>

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