Multiplex Detection of Oxidative Phosphorylation as a Mechanistic Indicator for Drug Induced Mitochondrial Toxicity

Drug-induced mitochondrial toxicity is a problem that is receiving growing attention. Many widely prescribed therapeutics have "off-target" effects on mitochondria that impair function through several mechanisms. Growing evidence shows that mitochondrial malfunction is linked to several chronic diseases, such as diabetes, cancer and neurodegenerative disorders. Oxidative phosphorylation (OXPHOS) produces more than 95% of the conserved cellular energy in the form of ATP under normal conditions. In this poster learn how mitochondrial toxicity can be assessed with the help of the MILLIPLEX® MAP Human Oxidative Phosphorylation (OXPHOS) Magnetic Bead Panel.