New Clarity® Oligo-WAX™ LC Media Improves Preparative Purification

Phenomenex Inc., a leading worldwide manufacturer of separation science consumables, introduces a new line of columns for preparative chromatographic purification of synthetic DNA and RNA. The new Clarity Oligo-WAX media delivers high yields and purity coupled with high loading capacity. These new columns can be used in HPLC and FPLC systems.

Clarity Oligo-WAX media incorporates a cross-linked weak ion exchanger bonded to a 10 µm high-purity silica, producing sharper peaks than traditional polymer alternatives. The high-density ligand provides a higher loading capacity along with better fractionation of closely eluting compounds than other media. Oligo-WAX can also be used at higher flow rates and pressures for increased productivity.

“Research and development use of synthetic DNA and RNA is on the rise and manufacturers are continually looking for ways to increase output of highly purified oligonucleotides,” explained Cathy Cordova, brand manager for Phenomenex. “Clarity Oligo-WAX is an entirely new solution, delivering unique advantages over other preparative-scale ion exchange media.”

The new Oligo-WAX columns are part of Phenomenex’s Clarity BioSolutions portfolio of products for synthetic oligonucleotide purification. The product portfolio consists of pre-packed columns in analytical to preparative dimensions as well as bulk material. From low purity/low loading to high purity/high loading tools, Phenomenex offers a range of solutions along with hands-on technical and applications support.