Next Generation Single-Use Bioreactor Improves Cell Culture Performance

The next-generation HyPerforma Single-Use Bioreactor has been redesigned to provide improved ergonomics while retaining traditional stainless steel bioreactor design principles to enhance cell culture performance.

The next generation bioreactor -- Thermo Scientific HyPerforma Single-Use Bioreactor (S.U.B.) -- offers all of the advantages of previous S.U.B.s while offering advancements that make it easier to manage tubing systems and loading of single-use Thermo Scientific bioprocess containers, as well as faster heat up and cool down, flexible positioning, and height-adjustable single- or dual-filter brackets.

The new line also offers a smaller footprint to optimize space and a cable management tree to reduce clutter in the production labs. A vertical access door on larger S.U.B.s also simplifies the bioprocess container loading process.

“We have gained experience and worked closely with our customers to develop a next-generation single-use bioreactor that matches performance of its predecessors while providing even better usability,” said Millie Ullah, senior product manager for single-use systems at Thermo Fisher Scientific. “The initial feedback from our customers has been overwhelmingly positive.”

Thermo Fisher showcased its new S.U.B systems this week at the BioProcess International Conference and Exhibition, September 17-19, 2013, Hynes Convention Center, Booth # 611.

The six available sizes (50L, 100L, 250L, 500L, 1000L and 2000L) can be integrated with a choice of control systems either as an open architecture solution or a turn-key system that is shipped with a dedicated controller from Finesse or Applikon. The supported software platforms include PC, Delta V, EZ, Allen Bradley and Siemens (PLC) to give customers a broad range of choices for cGMP and non-cGMP manufacturing.

In 2006, Thermo Fisher launched the first stirred-tank single-use bioreactor (SUB) and today more than 85 percent of the top biopharma companies employ Thermo Scientific HyPerforma bioreactors. Available in six sizes from 50-2000L, the bioreactor is known for providing consistent results from small to large scale cell culture processing.