NimbleGen Multiplex Gene-expression Arrays and Services

Roche Applied Sciences enhances its expanding product range of analysis instruments for genomics and epigenomics by means of the arrays and services for the analysis in the field of pro- and eukaryotic gene-expression of Roche NimbleGen. The new NimbleChip™ Multiplex Arrays provide the opportunity of hybridizing 4 samples simultaneously which leads to an efficient and economical analysis. Due to Roche NimbleGen’s long oligonucleotid probes (60mer) in combination with an extreme high probe density on the sub-arrays (each 72,000 probes) the user can analyze whole genomes with multiple probes for every gene. The increased number of probes (usually 3 – 7 per gene) supplies an excellent statistical rate of reliability and vastly improves the capacity for reproduction. This is a major advantage in comparison to platforms which function with only one to two probes per gene.

Designs of whole genomes in the multiplex format are available for a variety of species, e.g. human, mice, rats, Saccharomyces cerevisiae, Schizosaccharomyces pombe, Arabidopsis thaliana, Caenorhabditis elegans, and Drosophila melanogaster. Upon request, arrays in the 4-plex format can be produced for every pro- and eukaryotic organism with a well-described genome.

Roche NimbleGen’s exclusive high density arrays with long oligonucleotid probes deliver outstanding results for the 2nd generation genome analysis methods e.g., Array-CGH, ChIP-chip, methylation profiling, and expression tiling. The copyright protected Roche NimbleGen Maskless Array Synthesis (MAS) technology uses digital light processing and high-performance photo chemistry and also enables a large degree of flexibility in the production of arrays for various different areas of application.

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