Novus Biologicals Announces New Ion-Channel Polyclonal Antibodies

Novus Biologicals recently launched nine new antibodies associated with ion-channel processes of the cell. These primary antibodies are all rabbit polyclonal and include genes involved in voltage-dependent calcium channels, voltage-gated potassium channels, and oxidative phosphorylation in ATP synthesis.

These new antibodies include: CACNA1C antibody (NBP1-42817), CACNA1C blocking antibody (NBP1-42820), Kv1 antibody (NBP1-42788), KCNH1 antibody (NBP1-42816), Kv1.2 blocking antibody (NBP1-42818), Kv1.2 antibody (NBP1-42802), Kv3.1 antibody (NBP1-42819), ATP5E (human) antibody (NBP1-42805), ATP5E (drosophila) antibody (NBP1-42813). Sample sizes are available for all of these new ion-channel antibodies.

Calcium channels regulate the gradient of calcium ions across the cell membrane. Both of the two new CACNA1C antibodies encode for an alpha-1 subunit of a calcium ion channel. A calcium channel is made up of complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. The alpha-1 subunit is inhibited by dihydropyridine.

Voltage-gated potassium channels are very complex structurally and functionally. They mediate potassium levels inside a cell by adjusting the permeability to K+ in response to voltage differences across the membrane. The Kv1.2 antibodies bind to PDZ domains of DLG1, DLG2, and DLG4 and mostly contribute to the regulation of the opening and closing of channel pores. The Kv1 subfamily may be associated with fast repolarization of action potentials in the heart and contribute to the duration of heart action potentials. The Kv3.1 and KCNH1 antibodies are both involved in action potentials of neurons in the brain. Other functions of voltage-gated potassium channels include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume.

The ATP5E gene encodes for a portion of the catalytic core of mitochondrial ATP synthase. Mitochondrial ATP synthase is important in catalyzing ATP synthesis. It acts as a catalyst by using an electrochemical proton gradient across the inner membrane of the cell during oxidative phosphorylation. NBP1-42805 reacts in many species including humans, whereas NBP1-42813 reacts only in Drosophila.

Use the Novus Explorer to investigate the genes, pathways and diseases associated with these new antibodies. For information about these antibodies, browse Novus Biological's antibody database.