Novus Biologicals Launches a New Anti-CLOCK Antibody for Circadian Rhythm Research

The CLOCK protein, also known as KAT13D, belongs to the basic helix-loop-helix (bHLH) family of transcription factors. It is a major protein of interest in the study of circadian rhythm as polymorphisms within the encoded protein have been shown to be associated with abnormal circadian rhythm behavior, such as sleep disorders.

Novus' new CLOCK antibody is an affinity purified, rabbit polyclonal antibody. It was made to a synthetic peptide made to a C-terminal portion of the mouse protein within residues 805-855 (Swiss-Prot O08785). This antibody was QC tested in Western blot on human brain lysate where a band can be seen at 95kDa, however it is also reactive with mouse and the immunogen has 94% identity with rat.

Circadian clocks are responsible for the regulation of hormonal rhythms, sleep cycles, body temperature, blood pressure, and other behaviors. The suprachiasmatic nucleus (SCN), which is located in the brain, was the first mammalian circadian clock to be discovered. Novus provides additional information on circadian rhythm research and their new CLOCK antibody on the Circadian Rhythm Research Center page of their website.

CLOCK has been shown to interact strongly with other bHLH-PAS proteins such as BMAL1. Novus also offers other antibodies useful for the study of circadian rhythms, including Serotonin N-acetyltransferase antibodies, BMAL1 antibodies, Cryptochrome antibodies, PER1 antibodies, PER2 antibodies and Timeless antibodies.

Order details: catalog #: NBP1-30326