Raman spectroscopy as a PAT tool in a continuous perfusion run

The biopharmaceutical industry is driven by the need to increase production and reduce costs while maintaining product quality. One effective way to achieve this goal is to streamline the monitoring process of biologics production, thus allowing more effective control of production parameters. Explore how Process Raman can be used for real-time, in-line monitoring of critical process parameters (CPPs) in high-density mammalian perfusion cell cultures, achieving densities of 100–130 million cells/mL. The Thermo Scientific™ MarqMetrix™ All-In-One Process Raman Analyzer System enables monitoring of specific critical process parameters (CPPs) like glucose, lactate, ammonium, product titer, and cell viability over a 50-day continuous perfusion bioreactor run, enhancing control and efficiency in biologics production.