Synamatix Announces Release of Bioinformatics Solutions for Second Generation Sequencers

Synamatix announced today the release of two new software applications designed to process and analyse data from large-scale re-sequencing projects conducted with second generation DNA sequencing platforms.

Robert Hercus, Synamatix Managing Director, commented, “SXOligosearch™ and a modified version of SynaSearch™ have been released to address the growing explosion of data from the increasing use of the 454-Roche and Solexa-Illumina DNA sequencing platforms. These applications were developed as part of an ongoing strategy to complete a suite of high-throughput applications to process, analyse and integrate data from every type of second generation DNA sequencer.”

The first application, SXOligosearch, is designed to map short sequences such as reads from the Solexa-Illumina genome sequencer or oligonucleotide microarray probes. It offers a very high degree of flexibility in terms of handling a wide variety of read errors or mutations. In addition, more than a 100-fold improvement in performance compared to conventional tools is observed. Unlike other industry standard alignment tools, SXOligosearch aligns complete reads rather than HSPs resulting in higher specificity and sensitivity. It is also able to handle low-quality reads containing any number of mismatches, insertions or deletions with high accuracy and superior performance.

A new version of SynaSearch, modified to process and map reads from the GS20 and FLX platforms from 454, has also been released. Careful optimisation has resulted in increased accuracy, specificity and a 200-fold improvement in performance compared to standard approaches.

By using SynaBASE™ as a common platform, various types of reads can be mixed to increase coverage and deepen support for differences that are identified between data sets.

Synamatix’s other high-performance applications based upon SynaBASE, its unique structured network database platform, include SynaTree™, SXPRESearch™ and SXProbeDB™.