Synthesis of custom DNA-peptide conjugates

Activotec has announced a new synthesis service for custom DNA-peptide conjugates using the native chemical ligation approach involving linking a cysteine in one moiety (either peptide or DNA), to an activated thioester terminus in the other. Customers can provide their own DNA or peptide for conjugation or Activotec can synthesise the DNA and peptide to be conjugated.

Using solid and solution phase chemistries, employing Fmoc and t-Boc methodologies, Activotec has established an international reputation for custom production of a wide range of high quality peptides that are difficult to make via other techniques.

For many years - Activotec's custom peptide facility has been providing customers around the world with the highest-quality peptides at competitive prices. Operating out of a modern peptide synthesis facility in the UK the company is able to provide in fast delivery times milligram (mg) to multiple grams of peptides at all required purity levels and with any modifications required. Particular expertise focuses on difficult-to-synthesise sequences, non-natural modifications, and the design and synthesis of highly effective peptide therapeutics.

The quality of every DNA-peptide conjugate produced by Activotec is guaranteed. All custom peptides are purified by RP-HPLC to a guaranteed quoted purity. Every DNA-peptide conjugate is delivered with individual mass spectroscopic and analytical HPLC data.