Thermo Fisher Scientific Announces Three New Products for Easier, Faster Quantitative Proteomic Analysis

Fisher Scientific Inc., the world leader in serving science, announced today at the American Society of Mass Spectrometry (ASMS) 2009 annual conference the launch of two new products designed to increase the productivity of quantitative proteomics research.

The products are Intelligent Selected Reaction Monitoring (iSRM), which improves the throughput of SRM assays, and Pinpoint software for automated method development and quantitative analysis of SRM-based targeted peptide assays. These products will be on display at the Thermo Scientific hospitality suite at the Philadelphia Marriott Downtown in Salons G-K during the ASMS conference, which runs from May 31-June 4 in Philadelphia.

“Proteomics researchers have largely shifted their focus from high-throughput protein identification to measuring protein expression changes via relative quantitation, which may give clues to the role those proteins play in disease,” said Amy Zumwalt, proteomics marketing programs manager for life sciences mass spectrometry at Thermo Fisher Scientific. “With products like iSRM and Pinpoint, Thermo Fisher Scientific is leading the industry in providing high-performance, easy-to-use technology that functions in a single, seamless workflow for proteomics discovery.”

iSRM and Pinpoint software enhance targeted protein quantitation
One of the biggest challenges in proteomics quantitation is to simultaneously verify and quantify low-level biomarkers. iSRM, which is available on all Thermo Scientific TSQ (triple stage quadrupole) instruments, increases the sensitivity and selectivity of targeted quantitation assays for simultaneously verifying and quantifying targeted proteins.

“With traditional SRM-based assays, the user always had to compromise between selectivity and sensitivity,” said Andreas Huhmer, proteomics marketing director for life sciences mass spectrometry at Thermo Fisher Scientific. “With iSRM, the instrument maintains high sensitivity and high selectivity. iSRM is designed to target as many as 1000 peptides and handle over 10,000 SRM transitions in a single experiment. These numbers are higher than past technologies could deliver. As such, iSRM has the potential to significantly decrease labor and cost per analysis by increasing the number of peptides targeted in a single analysis.”

As part of this integrated targeted quantitation workflow, Thermo Fisher Scientific is also introducing Pinpoint software. Pinpoint, available as a free download, is designed to simplify the transition from early-stage biomarker discovery to larger-scale, quantitative verification of putative biomarkers and general quantitative proteomics.

For more information about iSRM and Pinpoint software, please visit the Thermo Scientific hospitality suite at the Philadelphia Marriot Downtown in Salons G-K during ASMS 2009. For more information about Thermo Scientific mass spectrometry solutions, please follow the company article webpage link on the right hand side of the screen.