Thermo Fisher Scientific Debuts Next-Generation Ion Trap and Orbitrap Mass Spectrometers at Pittcon 2010

The LTQ VelosTM, which features a new dual-pressure trap and advanced ion optics, is the world's fastest and most sensitive ion trap mass spectrometer. The LTQ Orbitrap VelosTM combines the industry-leading OrbitrapTM mass analyzer, a new higher-energy collisional dissociation (HCD) cell and dual-pressure trap technology to deliver ultra-high resolution and accurate mass data.

LTQ Velos - Reinvention of ion trap technology
For proteomics applications, the improvements in speed and sensitivity provide greater coverage in the analysis of complex peptide mixtures, increasing the confidence of protein identification at low sample levels. The multiple fragmentation techniques available on the LTQ Velos enable more confident sequence assignment and post-translational modification (PTM) identification. Faster scan rates reduce cycle times by up to 50 percent, doubling the number of proteins and peptides identified.

For metabolism applications, the dual-pressure trap technology increases fragmentation efficiencies, resulting in faster and more confident structural elucidation. The improved speed and enhanced sensitivity combines with MSn capabilities, maximizing throughput while maintaining the superior data quality required for the identification and quantitation of multiple co-eluting compounds.

The LTQ Velos can be upgraded to the LTQ Orbitrap Velos, allowing laboratories to extend their initial investment to include accurate mass and ultra-high resolution capabilities with no compromise to sensitivity and speed of analysis.

Instrument Business Outlook selected the LTQ Velos ion trap liquid chromatography/mass spectrometry (LC/MS) system as its "Product of the Show" during the American Society of Mass Spectrometry 2009 meeting.

LTQ Orbitrap Velos - Powered by Orbitrap technology
The LTQ Orbitrap Velos combines the proven mass accuracy and ultra-high resolution of the Orbitrap mass analyzer with the increased sensitivity and improved cycle time of the LTQ Velos to deliver high-performance hybrid mass spectrometry.

The high mass accuracy of the LTQ Orbitrap Velos increases the speed and confidence of protein identification in complex samples by minimizing false positives. The ultra-high resolution delivers certainty in analytical results by enabling molecular weight determination for intact proteins and in-depth analysis of isobaric species. For proteomics researchers, these capabilities enable the identification of more proteins with increased sequence coverage and higher confidence.

The new HCD cell in the LTQ Orbitrap Velos is more efficient, resulting in improved quantitation of isobarically labeled peptides. This includes applications requiring tandem mass tags (TMT). Electron transfer dissociation (ETD) generates complementary information for highly sensitive PTM analyses and de novo sequencing.

For metabolism applications, the LTQ Orbitrap Velos provides researchers with high resolution accurate mass data for more confident structural elucidation.

With these new features, Thermo Scientific LTQ Orbitrap technology remains the most comprehensive structural identification mass spectrometry instrument and the platform of choice for the most confident protein and metabolite identification, characterization and quantitation.

The speed of both LTQ Velos mass spectrometers is ideal for coupling with ultra-high performance liquid chromatography (U-HPLC) systems, enabling researchers to identify more compounds in less time.