Thermo Fisher Scientific introduces Invitrogen Vivofectamine Delivery Solutions

Thermo Fisher Scientific has introduced Invitrogen™ Vivofectamine™ Delivery Solutions to provide high-performance lipid nanoparticles (LNP) technology for non-viral delivery of nucleic acids, helping advance life science research and genetic medicine development. This innovative LNP portfolio, curated from over 6,000 rationally designed, chemically diverse ionizable lipids, offers in vivo delivery solutions in various application areas with the desired efficiency, specificity and safety profiles.

Invitrogen’s Vivofectamine Delivery Solutions offer two tailored portfolios: the basic research portfolio with catalog LNP reagents for academic researchers, and the drug development portfolio with custom LNP reagents and services for drug developers.

Features/benefits:

• Versatility: The Vivofectamine LNPs were developed through iterative cycles of rational ionizable lipid design, synthesis, formulation optimization, characterization, and in vitro and in vivo biological screening. They are available in a variety of reagent formats and come with value-added services. Additionally, adaptable licensing terms are offered to tailor to different drug developers’ needs.
• Safety: Various Vivofectamine LNPs were tested by collaborators through repeated, escalated dosing and maximum tolerated dose regimes in non-human primates and rat studies and benchmarked against leading LNPs used in relevant clinical stage or FDA approved drugs.
• Helping accelerate innovation with proven in vivo delivery solutions: Vivofectamine LNPs have been extensively optimized and tested in multiple animal models for intramuscular delivery in prophylactic and cancer vaccines, as well as systemic delivery to the liver. Thermo Fisher's collaborators have also shared preliminary feasibility data on extra-hepatic systemic delivery to immune cells, muscles, and local delivery, to areas such as tumors, eyes, adipose tissue, and the central nervous system.

Invitrogen Vivofectamine Delivery Solutions are intended for research use only, Not for use in diagnostic procedures. They are suitable for institutions conducting basic research, as well as biotechnology and biopharmaceutical companies involved in drug development for nucleic acid modalities.

Want the latest science news straight to your inbox? Become a SelectScience member for free today>>