Thermo Fisher Scientific Showcases New Integrated LC-MS Drug Discovery Workflow for Maximizing Sample Throughput

Thermo Fisher Scientific Inc., the world leader in serving science, today announced the integration of Thermo Scientific Aria™ LX multiplexing technology with QuickQuan™ software. The combination enables users to increase the throughput of compounds processed in high-throughput liquid chromatography-mass spectrometry (LC-MS) assays by a factor of four. This instrument accelerates the pace of drug discovery for pharmaceutical companies, streamlining the workflow by maximizing the productivity of a single MS detector. The complete system will be showcased at the Thermo Scientific booth 1741 at PITTCON 2008, being held March 3–6 in New Orleans.

The unique Thermo Scientific multiplexing technology is the only truly independent, parallel, multichannel system in the industry, bringing the productivity of up to four separate LC systems to a single MS. The Thermo Scientific TSQ Quantum™ triple quadrupole mass spectrometer and an Aria LX-4 System can process as many samples as four standalone LC-MS/MS systems. The multiplexed system ensures maximum performance of the MS so the user can boost productivity without compromising data quality or sensitivity.

For laboratories that perform high-throughput screening, this integrated solution allows scientists to quickly assess thousands of new chemical entity samples in drug discovery research. QuickQuan software performs automated optimization of MS/MS parameters, enabling the rapid analysis of compounds. Data generated from QuickQuan can be seamlessly transferred to the Thermo Scientific Galileo LIMS™ or QuickCalc™ software powered by Gubbs Inc. GMSU.

“The integration of these innovative Thermo Scientific products into a single solution demonstrates Thermo Fisher’s commitment to developing technologies for our customers that simplify their processes and improve laboratory productivity,” said Dr. Ian Jardine, vice president of global research and development for Thermo Fisher Scientific. “As the leader in mass spectrometry, we have an unmatched portfolio that enables us to develop sophisticated, yet intuitive, workflows for our customers.”