Thermo Unveils New Proteomics Capabilities that Improve Quantitation and Characterization

Thermo Electron Corporation, the world leader in analytical instrumentation, unveils several new additions to its Proteomicsⁿ suite of solutions.

These include Thermo’s novel LTQ Orbitrap™ hybrid mass spectrometer, new techniques for peptide fragmentation and software for data interpretation, all which dramatically enhance and expand the potential for protein identification and quantification. The Proteomicsn suite will be showcased on Thermo’s booth #112, 114 & 116 at ABRF 2006, Long Beach Convention Center, Long Beach, California, Feb 11-14.

Thermo’s Proteomicsⁿ solutions are designed to leverage the unmatched performance, speed, sensitivity and accuracy of their market-leading ion trap mass spectrometers for definitive quantitation of protein mixtures. Some of these new solutions include the LTQ Orbitrap, the first commercial mass analyzer based on an entirely new detection principle to be introduced to the market in over 20 years. This hybrid instrument greatly improves protein characterization, accelerates protein database searches and reduces false identification rates.

Thermo has also introduced several new approaches to protein quantitation, such as Pulsed-Q Dissociation (PQD), a new fragmentation technique that eliminates the low mass cut-off for ion traps and allows quantitation with iTRAQ™ labeling reagents. iTRAQ is a stable isotope method for relative protein quantitation using mass spectrometry.

In addition, BioWorks™ software has been extended to facilitate the use of all major protein quantitation techniques, namely SILAC (Stable Isotope Labeling with Amino Acids in Cell Culture), metabolic labeling, iTRAQ and ICAT™ (Isotope Coding Affinity Tagging). As a result, SEQUESTÒ protein identifications can now easily be combined with quantitative data for an accurate view of protein expression levels.

For more information about Thermo’s Proteomicsⁿ suite of products, please visit Thermo’s booth #112, 114 & 116 at ABRF 2006 in Long Beach, California.