TLC-to-Step Gradient Capability of New Isolera Spektra Software Significantly Reduces Both Purification Time and Solvent Use

Biotage, a leading global supplier of solutions and technology for analytical, medicinal and peptide chemistry, has announced the launch of an updated version of its Isolera™ Spektra software with improvements to the time and solvent saving step gradient optimization feature. The updated software uses TLC data from 2 to 10 different TLC runs to estimate where the individual sample components will elute, the percentage of strong solvent required and which cartridge is best capable of purifying the amount of sample to be purified.

This patent-pending technology helps chemists to tailor the purification to separate and purify between one and six compounds in the sample or even target one specific compound of interest, which can reduce purification costs 60% or more over conventional, non-compound specific linear gradients. Furthermore, the simplicity of the software makes it easy for even the most inexperienced users to take advantage of sophisticated purification strategies.

“The launch of the Biotage® Isolera™ Spektra in 2012 was a revolution in flash purification, moving 1-dimensional flash into 2D and 3D with a purification system capable of targeting specific compounds in complex mixtures, and even detecting the presence of normally invisible impurities beneath peaks of interest. It has and will continue to positively change the way we think about flash purification” says Dr. Sunil Rana, Product Manager, Biotage®. “This latest update extends the step-gradient application range to include the new high capacity Biotage® SNAP Ultra and Biotage ZIP® Sphere cartridges.”