Market Needs
Modern life science and biotech applications require detection of the biocatalytical activity of a specific enzyme in live cells without the use of antibodies. However, today’s marketed chromogenic substrates suffer from low performance while fluorogenic ones lack robustness. The use of enzyme-responsive probes releasing a precipitated signal can meet the significant challenges, i.e. sensitivity, fast response time, and signal retention, imposed by industrial sectors as diverse as the identification of microorganisms, in situ cancer diagnosis, or high-throughput enzyme assays at the R&D level.
Origins
Many reports of these past 20 years have highlighted the unique properties of the solid-state fluorophore HPQ (also known as "ELF 97 alcohol”). HPQ is a highly attractive candidate for the incorporation into enzyme-responsive molecular probes that furnish high sensitivity, rapid response, and signal retention. The only probe marketed to date responds to generic phosphatase activity and is particularly proposed for immunohistochemical assays; it's performance is also cherished by specialists of microbial analysis of natural water bodies.
Breakthrough
Based on a published technology developed by the team of Pr Jens Hasserodt at the ENS of Lyon (France), Molsid today benefits of an exclusive licence to produce the broadest range of robust fluorogenic precipitation-based probes available on the market. We offer unsurpassed fast and sensitive fluorescence detection for a large panel of enzymes for industrial and R&D applications.
Our multi-skilled team includes competencies in R&D, production, finance and marketing. We are based in Lyon, within the ENS facilities.