Sensitive and robust analytical tools and methods are essential for accurate detection, risk assessment, regulatory compliance, efficient treatment, and informed decision-making concerning PFAS in wastewater. Current PFAS analysis technologies have made significant advancements in sensitivity, but challenges persist. The sensitivity required for PFAS analysis is exceptionally high due to their harmful effects even at very low concentration.

In response to this challenge, a comprehensive workflow has been devised for effective PFAS analysis in wastewater. This innovative approach builds on the EPA draft Method 1633, integrating additional PFAS variants in terms of size and functional groups. The workflow encompasses offline solid phase extraction (SPE), a crucial cleanup step, LC-MS/MS analysis, and automated reporting, culminating in a highly reliable solution for precisely analyzing targeted PFAS in complex matrices while maintaining robustness.

To further aid scientists and analysts in this critical pursuit, Agilent presents an advanced methodology for the separation and detection of 28 PFAS compounds in water samples. This comprehensive method leverages  state-of-the-art LC/MS technology, supported with software. This methodology covers all PFASs outlined in the ASTM 7979 method, utilizing the same sample preparation protocol. With a reporting limit of 10 parts per trillion (ppt, ng/L) or lower for most compounds, this technique offers a highly sensitive approach to precisely analyze PFAS in water samples.

Revident quadrupole time-of-flight LC/MS (LC/Q-TOF)

The Revident LC/Q-TOF embodies the next generation of quadrupole time-of-flight instruments featuring truly innovative (electronic) instrument architecture, instrument intelligence, a novel, ultrafast detector, and an updated, robust calibrant delivery system.

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The presence of PFAS in biofluids has garnered significant attention from the media, public, and government regulators. PFAS have come under intense scrutiny due to their persistent nature and inherent toxicity, demanding a thorough exploration of their presence and effects within the human body.

In the public eye and regulatory discussions, a majority of the focus centers on a limited set of PFAS, primarily PFOA and PFOS. However, the scope of conventional targeted methods is often restricted to measuring around 30 PFAS compounds, leaving a considerable gap in the assessment of these substances and their potential impact on human health.

To bridge this analytical gap and comprehend the comprehensive implications of PFAS loads on human health, there is a compelling need for non-targeted PFAS analysis. This approach is essential to broaden the coverage of PFAS measurement, encompassing the lesser-measured or unknown PFAS variants that are continually emerging with evolving manufacturing practices. Understanding the full spectrum of PFAS is critical for a comprehensive assessment of their impact on human health and the environment.

In response to this demand, Agilent has introduced FluoroMatch 3.0 – an innovative tool designed to elevate PFAS analysis. This version presents new developments and advancements in PFAS analysis methodologies. Explore its application to dried blood spots, providing a deeper understanding of PFAS exposure and shedding light on previously unexplored aspects of their presence in biofluids.

Explore Agilent's tips, tricks, resources, and research to learn how to:

• Quickly set up robust PFAS testing with an easy-to-use eMethod that includes a step-by-step workflow guide and ready-to-run acquisition and quantitation methods
  

• Analyze a wide range of PFAS compounds with a method to detect over 100 native and isotopically labeled PFAS compounds in drinking water and wastewater
  

• Meet evolving PFAS testing needs with methods that include target compounds that are part of standard methods and regulatory lists, suchas US EPA, ASTM and ISO methods, European Union methods, Germany DIN methods, and Japan Drinking Water Quality Standards
  

• How LC/TQ, GC/TQ, LC & GC-Q/TOF along with other techniques will be required to completely characterize PFAS in the future
  

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How Weck Laboratories stays ahead in PFAS testing

Find out how Weck Laboratories is harnessing the capabilities of Agilent’s cutting-edge technology to revolutionize their PFAS analysis. Discover how this customer's experience with advanced solutions has streamlined their processes and enhanced their results, paving the way for more accurate and impactful environmental insights.