Products & ReviewLife Sciences
1-Azakenpaullone
Inhibits glycogen synthase kinase 3ß (GSK3ß)
1-Azakenpaullone
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1-Azakenpaullone is a potent and highly selective inhibitor of glycogen synthase kinase 3β (IC₅₀ = 18 nM) and is highly preferential to GSK3β versus other cyclin-dependent kinases (CDKs) including CDK/cyclin B and CDK5/p25 (IC₅₀ = 2 µM and 4.2 µM, respectively; Kunick et al.).
MAINTENANCE AND SELF-RENEWAL
- In combination with ID-8 (Catalog #72502) and FK506 (Catalog #74152), supports human pluripotent stem cells in long-term propagation, maintaining pluripotency, and capacity to differentiate (Yasuda et al.).
