Acrodisc sterile syringe filters
Syringe filters with high flow rates and low protein binding
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Key to method development
Preparation of high-protein hydrophilic samples
I found them to be highly effective at filtration of samples with high protein. The polyethersulfone membrane can handle high backpressure without rupturing while filtering the samples very nicely for LC analysis.
Review Date: 4 Mar 2024 | Cytiva
Acrodisc™ syringe filters with Supor™ membrane, a Pall Life Sciences product, deliver high flow rates and low protein binding.
- Superior flow rates and higher throughputs than competitive devices.
- Low protein binding to minimize sample loss.
- Pre-sterilized products are sterilized by gamma irradiation to eliminate potential contamination by EtO residuals.
- A range of sizes (13 to 37 mm) accommodates sample volumes from < 10 to 150 mL.
- Acrodisc PF and Serum Acrodisc syringe filters feature built-in prefilter for increased throughput of difficult-to-filter liquids.
- Reduces mycoplasma with the use of 0.1 μm pore size.
Specifications
Materials of construction
Filter Media: Supor™ membrane [hydrophilic polyethersulfone (PES)]
Serum Acrodisc™ Prefilter Media: Binder-free borosilicate glass
Acrodisc Housing:
13 mm: Polypropylene
25 and 32 mm: Modified acrylic
37 mm: Polypropylene
Serum Acrodisc Housing: ABS
Pore Size
0.1, 0.2, 0.45, 0.8, 1.2, and 5 µm
Effective Filtration Area
13 mm: 1.0 cm2
25 mm: 2.8 cm2
32 mm: 5.8 cm2
37 mm: 7.5 cm2
Inlet/Outlet Connections
Female luer lock inlet, male slip luer outlet
Typical Hold-Up Volume
(with air purge)
13 mm: < 28 µL
25 mm: < 70 µL
32 and 37 mm: <100 µL
Maximum Operating Temperature
55°C (131°F)
Maximum Operating Pressure
5.2 bar (520 kPa, 75 psi)
Typical Water Flow Rate
mL/min at 3.1 bar (310 kPa, 45 psi)
0.1 μm, 25 mm: 35
0.1 μm, 32 mm: 100
0.2 μm, 13 mm: 22
0.2 μm, 25 mm: 175
0.2 μm, 32 mm: 490
0.45 μm, 13 mm: 35
0.45 μm, 25 mm: 300
0.45 μm, 32 mm: 700
0.8 μm, 13 mm: 150
0.8 μm, 25 mm: 700
0.8/0.2 μm, 25 mm: 145
0.8/0.2 μm, 32 mm: 440
1.2 μm, 32 mm: 1700
5 μm, 32 mm: 1750
GF/0.2 μm, 37 mm (Serum Acrodisc Filter): 425
Endotoxin Level
13mm, 25mm and 37mm: < 0.25 EU/mL using Limulus Amoebocyte Lysate (LAL)
32mm: <0.5EU/mL using Limulus Amoebocyte Lysate (LAL) test
Sterilization
Sterilized by gamma irradiation and individually blister packaged.
Applications
0.1 and 0.2 μm pore sizes provide sterilization of small volumes of buffers, culture media, and additives.
Acrodisc PF and Serum Acrodisc syringe filters are ideal for clarification/sterilization of viscous or particulate-laden solutions.
Use larger pore size filters for prefiltration and particulate removal.
