Anti-idiotype Antibody Services
Guaranteed application in immunoassay development for PK and ADA analysis
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An anti-idiotype antibody (anti-ID Ab, see the schematic diagram) binds to the idiotype of another antibody, usually an antibody-drug. An idiotype can be defined as the specific combination of idiotopes present within an antibody complementary determining regions. Since anti-ID Abs are capable of binding to antibody-drugs within biological fluids, they are commonly used in the preclinical setting to analyze the pharmacokinetics (PK) and pharmacodynamics (PD) of antibody-drugs. Due to the similarity between anti-ID Abs and anti-drug antibodies, anti-ID Abs are also commonly used as a reference standard for antibody-drug immunogenicity, anti-drug antibody (ADA) studies, and neutralization antibody measurements.
Leveraging its extensive expertise in antibody development, GenScript partners with investigators just like you in developing highly sensitive and specific polyclonal and monoclonal anti-ID antibodies to best suit your particular downstream applications.
