ASSAY DEVELOPMENT AND OPTIMIZATION SERVICES
With over 30 years of experience developing and manufacturing ELISAs and ligand binding assays for commercial use, Mercodia has a profound understanding of product lifecycle management. To ensure that the assays we develop for drug development are reliable, accurate, and precise, we have product development procedures in place that cover all phases of the lifecycle from design, development, and validation to routine use.
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LIGAND BINDING ASSAYS
Ligand binding assays (LBAs) are widely used in drug development and key decisions are taken from the data. It is therefore important that the results are reliable. Our assay development services guarantee accurate and precise measurement of your biomarker of choice for the specific intended use, as well as for PK and PD studies. We deliver integrated bioanalytical solutions for your toughest assay needs.
Assay development
- Design of antigen binders
- Development of assays
- Assay validation for the context of use
- Assay manufacturing and supply (small and large scale)
Assay optimization
- Assay performance optimizations
- Reduction of interference
- Improvement of precision and reproducibility
- Lowering sample volume
- Shortening assay time
- Sample matrix adaptations (adapting the assay for alternative matrix)
- Ensure compliance with relevant guidelines
IMMUNOCAPTURE
Immunocapture, or Hybrid LC-MS, is a widely used technique for sample preparation before measuring proteins and peptides in complex matrices. By using Mercodia’s vast collection of antibodies or your own selected antibodies, we conjugate capture antibodies to magnetic beads for downstream analysis by LC-MS/MS, to provide an additional level of separation. Thanks to our expertise in antibody characterization and binding interactions, we can also help you in design, mapping and characterization of antibodies or binding targets. This approach may improve quantification of clinically relevant complex molecules, such as proteins and hormones, with a sensitivity that meets clinical needs.
