Products & ReviewLife Sciences
Bafilomycin A1
Inhibits autophagy and vacuolar H+-ATPase (V-ATPase)
Bafilomycin A1
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Bafilomycin A1 is a macrolide antibiotic drug and autophagy inhibitor. It prevents the acidification of autophagosomes via the inhibition of vacuolar H+-ATPase (V-ATPase; Klionsky et al.).
MAINTENANCE AND SELF-RENEWAL
- Inhibits the proteolytic degradation associated with autophagy in human mesenchymal stem cells (Oliver et al.).
CANCER RESEARCH
- At low concentrations, it inhibits autophagy and promotes apoptotic cell death in pediatric B cell acute lymphoblastic leukemia (B-ALL) cells (Yuan et al.).
