Beacon Discovery™

Experience the full potential of live single cell functional analysis with Beacon Discovery™. Powered by optofluidic technology, it enables researchers to explore multimodal and temporal cellular responses in real time, seamlessly linking functional data to sequencing from the same single cell for deeper scientific breakthroughs.
This accessible, compact, and flexible platform, with lower cost of ownership, delivers unparalleled insights into immune profiling, cell therapy, and antibody discovery. Whether identifying potent T cells, TILs, NK cells, or discovering high-affinity antibody-secreting B cells for challenging targets, Bruker Cellular Analysis’s Beacon^® portfolio delivers deepest functional insights from live single cells.

With the ability to screen thousands of live T cells and perform multiple functional assays per cell, including dynamic cytotoxicity, cytokine secretion, cell surface marker expression, scientists can comprehensively evaluate T cell potential in context and connect it with TCR-seq and transcriptomics data for the same single cells. For antibody discovery, this includes running multimodal functional assays, such as antigen specificity, cross-reactivity, affinity, membrane-bound antigen cell-binding, ligand blocking, and internalization, on tens of thousands of single B cells. The most promising antibody-secreting cells can be directly exported and sequenced, enabling a truly end-to-end antibody discovery workflow with a single platform.

Key Benefits:

• Exquisite Control: Build your own single cell experiments with unparalleled precision
• Live Cell Imaging: Capture real-time behaviors like biomolecule secretion, target killing, cell-cell interaction, and antigen binding
• Highest Parameters: Conduct multiple sequential assays on the same live single cells across hours or days
• Multiomics Connectivity: Identify and recover high-value cells to link phenotypic insights with downstream genomics and transcriptomics (TCR-seq, BCR-seq, mRNA-seq)
• Automated Scalability: Analyze 500 to 20,000 single cells enabling analysis of precious clinical samples or performing high throughput screening
• Accessible and Cost-effective: Empower low cost of ownership, compact benchtop footprint, and easy-to-use intuitive interface
• Flexible Workflows: Supports end-to-end pre-defined workflows and custom assay protocols for broad research applications
• Proven Technology: Built on Bruker Cellular Analysis’s widely published, validated optofluidic platform

Key Applications

• T Cell Profiling and TCR/CAR Discovery
• Tumor-Infiltrating Lymphocyte (TIL) Characterization
• Cell Therapy Development and Validation
• Translational Biomarker Discovery
• Antibody Discovery
• Antibody Profiling
• Vaccine Response Profiling

Ready to See What’s Possible?

Talk to a Bruker specialist to explore how live single-cell functional analysis and the Beacon Discovery can elevate your research.