BioPro HIC Columns from YMC: High Throughput and Loadability

BioPro HIC HT and BioPro HIC BF are based on a non-porous hydrophobic polymer to provide high resolution at very fast runs and therefore high throughput. They are designed and optimized for the analysis and lab-scale purification of antibodies, antibody-drug conjugates, and other proteins. BioPro HIC HT is designed for the analysis of biopharmaceuticals such as ADCs or MAbs. BioPro HIC BF shows stronger retention of proteins due to their higher hydrophobicity. It can therefore be used for the separation of low hydrophobic proteins or for oxidized MAbs since the oxidized variants elute earlier than the non-oxidized MAb.

Optimized surface modification and the column packing method result in high separation performance. The rigid particle provides higher pressure tolerance compared to other HIC columns, which allows higher flow rates and therefore shorter analysis times.

BioPro HIC Features:

• Designed for antibodies, antibody-drug conjugates, proteins
• High-performance separation
• High throughput analyses
• Excellent lot-to-lot reproducibility
• Long term stability
• Virtually no carry-over effects

BioPro HIC Characteristics:

• Non-porous butyl functionalized polymer beads for HIC separations
• Particle size: 2.3 and 4 µm
• pH range: 2 – 12
• Max. Temperature: up to 60°C