CAY10512

CAY10512 is an analog of Resveratrol that is 100-fold more potent (IC₅₀ = 150 nM) at inhibiting NF-κB activation by TNF-α (Heynekamp et al.). Unlike Resveratrol and some other trans-stilbene analogs, CAY10512 does not exhibit antioxidant activity (up to 15 μM) in either the ferric reducing/antioxidant power (FRAP) or total radical antioxidant parameter (TRAP) assays (Heynekamp et al.). Like Resveratrol, CAY10512 also inhibits lipopolysaccharide-induced expression of COX-2 (Heynekamp et al.).

IMMUNOLOGY

• Protects human islets from instant blood-mediated inflammatory response leading to improved survival of transplanted islets in in vitro tube model (Kanak et al.).

DISEASE MODELING

• Inhibits induction of NF-κB and subsequent upregulation of inflammatory microRNAs in Alzheimer disease model of human neuronal-glial cells in vitro (Lukiw).