Products & ReviewLife Sciences
CH223191
Aryl hydrocarbon receptor (AHR) antagonist
CH223191
The supplier does not provide quotations for this product through SelectScience. You can search for similar products in our Product Directory.
CH223191 is a potent and specific antagonist of the aryl hydrocarbon receptor (AhR) that blocks activation by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; IC₅₀ = 0.03 µM; Kim et al.). It prevents the induction of cytochrome P450 1A1 by TCDD in HepG2 cells and in livers of mice (Kim et al.).
MAINTENANCE AND SELF-RENEWAL
- Induces expansion of human CD34+ hematopoietic stem and progenitor cells in culture (Boitano et al.).
