Chromolith® HPLC Columns
Monolithic silica-based Chromolith® HPLC columns allow rapid separations at very low column backpressure with high matrix tolerance and extended column lifetime, thus making them ideal products for high throughput and cost-efficient analyses of matrix-rich samples.
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Review Date: 19 Nov 2022 | Merck
Chromolith® HPLC and UHPLC columns are made from monolithic silica with a bimodal pore structure using sol-gel technology. There are no silica particles.
Several key benefits result directly from the bimodal pore structure of the silica gel, which has 2 µm macropores and 13 nm mesopores:
- Rapid separations at very low column back-pressure
- Standard HPLC instruments are fully compatible with all Chromolith® columns and UHPLC instruments are fully compatible with Chromolith® UHPLC 2mm I.D. columns
- Matrix-rich samples (such as food or life science samples) can be analyzed without the need for sophisticated and time-consuming sample preparation. Guard column cartridges are also available.
- Cost-savings are achieved as the column lifetimes are much longer than for particulate HPLC columns, in particular when analyzing matrix-rich samples.
- Complex multi-component samples can be separated either by using Chromolith® HighResolution (HR) columns or by using long very high-efficiency columns formed by connecting two or more Chromolith® columns together. The low column backpressure makes this possible.
- Easy transfer of methods from a particulate column to a Chromolith® column.
- Chromolith® WP 300 columns are an excellent solution for the separation of Biomolecules
The columns are available not only with octadecyl (RP-18e) or octyl (RP-8e) endcapped surface modification, but also with Phenyl, CN (nitrile), Diol and NH2 (amino) surface modification as well as an unmodified pure silica.
