Colchicine, Bioreagent

Colchicine is a tricyclic alkaloid that can stay in circulation for 20 to 40 hours post intake. Leucocytes harbour maximum colchicine. It contains three hexameric rings termed A, B and C.

Application
Colchicine has been used:

• as an inhibitor of tubulin polymerization in bone-marrow-derived macrophages
  for the inhibition of in vitro neurite outgrowth in human neuronal cells
• as microtubule destabilizer to induce peripheral neuropathy in induced pluripotent stem cell derived neurons (iPSC-Neurons)