Dextran sulfate sodium salt, colitis grade (MW 36,000 - 50,000)
Dextran sulfate sodium salt, or DSS, is a synthetic sulfated branched polysaccharide derivative of dextran that has multiple uses in biomedical and clinical research. One important property of DSS is to triggers colitis in mice and rats when administered in drinking water.
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Dextran sulfate sodium salt, or DSS, is a synthetic sulfated branched polysaccharide derivative of dextran that has multiple uses in biomedical and clinical research (see table below). One important property of DSS is to trigger colitis in mice and rats when administered in drinking water. DSS binds to medium-chain-length fatty acids in the colon and induces intestinal inflammation. MP Premium Dextran Sulfate Sodium Salt (MW = 36,000–50,000) from MP Biomedicals is one of the most widely used products based on peer-reviewed scientific publications. Over the past 15 years, 3,000+ scientific publications have cited the use of our DSS.
- Induces severe colitis (inflammatory bowel disease)
- Highest sulfur content – 19%
- Highest chirality - +104° of specific rotation
- Lowest pH – 6.2 at 1% solution
Dextran sulfate sodium (DSS) is one of the most common and effective compounds used for inducing ulcerative colitis in animals. The DSS colitis model has also been used extensively to study colon cancer development in relation to colonic inflammation, such as that occurring in patients with long-standing ulcerative colitis.
MP Biomedicals offers the gold standard of colitis model creation reagents - colitis grade dextran sulfate sodium salt (36,000-50,000) and colonic carcinogen azoxymethane (AOM).
Because of its high efficacy, MP Biomedical DSS is one of the most widely used DSS products in the scientific literature. Over the past 19 years, more than 10,000 scientific publications have cited the use of MP Biomedicals’ DSS products and reported successful animal model establishment.
